Community use of oral antibiotics transiently reprofiles the intestinal microbiome in young Bangladeshi children

The study examines the relationship between oral antibiotic use and antimicrobial resistance in 1093 Bangladeshi infants. The study found that 61% of children were cumulatively exposed to antibiotics, with 47% in the first 3 months. The study found that alpha diversity of the intestinal microbiome is reduced in children who received antibiotics within the previous 7 days, and the overall abundance of antimicrobial resistance genes declines over time. The presence of antimicrobial resistance genes is correlated to microbiome composition, and community use of antibiotics transiently reprofiles the gut microbiome in Bangladeshi children.